EXOSOMES AND EPIGENETIC SKIN REJUVENATION 

Exosomes are key biological messengers that play a critical role to intercellular communication and cell biology.

These nanoscale vesicles, measuring just 30-200 nanometres are enveloped by a phospholipid bilayer membrane that protects their precious cargo: a cocktail of bioactive molecules that are critical for cell communication and repair.

Let’s think of them as the 5G signals of our bodies - packed with vital cellular information - incredibly efficient in delivering their contents to target cells with a mission to activate, support, and connect cells, ensuring the body operates as a synchronized system.

Because of their nanoscale size and ability to penetrate the skin, exosomes are ideal for topical or cutaneous applications, where they can deliver powerful regenerative signals directly to skin cells. The goal is to rejuvenate, repair, and revitalize the skin in ways we’re only beginning to fully understand.

As research evolves, lab-engineered, highly-lyophilised biomimetic exosomes mimicking human biology (designed to be as close as possible to human-derived exosomes) are paving the way for a new era in aesthetic medicine by enhancing collagen production, cellular repair, and skin revitalisation.

Once activated, lab engineered exosomes create a transformative synergy, activating the skin’s natural regenerative processes while delivering deep hydration and enhanced cellular communication.

Enhanced formulations can include plant stem cell exosomes, derived from the resilient Edelweiss plant or Ginseng plant root, both renowned for its antioxidant and anti-inflammatory properties.

Activating solutions can further reinforce the power of exosomes: hyaluronic acid molecules to ensure hydration, peptides that amplify cellular activity, antioxidants to protect against oxidative stress, and condition media packed with nutrients and growth factors to maximize the synergy between the added components.

In aesthetic medicine, exosomes have been particularly promising in correcting pigmentation issues, such as melasma, by targeting inflammation in melanocytes, the cells responsible for producing melanin at either dermal or epidermal levels. By reducing inflammation, they help modulate melanocyte activity, leading to visible improvements in pigmentation and overall skin tone.

These multifaceted properties - anti-inflammatory, antioxidant, and regenerative - make exosomes a promising tool in aesthetic and medical applications, addressing a range of conditions with precision and efficacy.

Epigenetic skin regeneration, a revolutionary approach to skincare and rejuvenation.

Epigenetics refer to the regulation of gene expression without altering the underlying DNA-sequence. In the context of skin health, this means that certain signals or factors, as those delivered by exosomes coctails
can "switch on" or "switch off" specific genes involved in repair, regeneration, and inflammation control.

Exosomes act as messengers, delivering these signals directly to target cells and triggering beneficial genetic pathways.
For example, certain exosome solutions contain bioactive molecules, peptides, and growth factors that can influence the expression of genes responsible for collagen synthesis, elastin production, and cellular renewal. This targeted activation results in a cascade of regenerative processes, helping to reverse the effects of aging, environmental stressors, and damage leading to the ageing of the skin or the hair.

The multi-faceted action of exosomes could address a wide range of skin concerns. Thanks to their epigenetic activity and unparalleled delivery system, the treatment offers remarkable outcomes for diverse dermatological and aesthetic issues.

 

ADDITIONAL INSIGHTS

WHAT DOES "HIGHLY LYOPHILISED" MEAN?

When we say that the exosomes are highly lyophilised, we are referring to an advanced preservation process that ensures the highest level of purity and stability. In simple terms, lyophilisation removes all water content from the exosomes, leaving them in a vacuum-packed, air-free state. This eliminates the need for refrigeration, offering more convenience and shelf stability.

The lyophilisation process not only preserves the exosomes but also ensures their remarkable purity – titrated at 99.9%, to be precise. Because exosomes are nanosized and highly concentrated, the result is a small amount of pure powder in a vial packed with billions of powerful cellular messengers ready to deliver transformative effects when reconstituted.

HIGHLY LYOPHILISED VS. LIQUID EXOSOMES

The primary difference between highly lyophilised exosomes and liquid exosome formulations lies in their stability. Lyophilised exosomes are completely free of water, vacuum-packed, and protected from air exposure. This not only ensures an exceptionally high purity (99.9%) but also eliminates the need for refrigeration, making storage and transport far easier and more reliable.

In contrast, liquid exosome formulations often require careful refrigeration or freezing to maintain their stability, as they are more prone to degradation when exposed to temperature fluctuations or environmental factors. In addition the concentrated, nanosized form ensures that a smaller amount delivers a potent effect, while their air and moisture-free state
preserves their functional integrity, ensuring they remain just as effective when reconstituted.

SYNERGY WITH ENERGY BASED DEVICES

Exosomes can work synergistically with energy-based devices, enhancing their overall effectiveness, while reducing their downtime. Exosomes are remarkably stable, maintaining their structure and function even when tested at high temperatures, as high as 80°C. This resilience ensures their compatibility with procedures involving heat or energy, such as lasers, fractional lasers, radiofrequency and RF microneedling, without compromising their therapeutic potential.

The combination of an energy-based device or technique creating absorption-channels (i.e. microneedling) with exosomes results in a powerful cumulative effect. The dual action accelerates the healing process, with potential improvements in skin texture and tone appearing almost immediately, while any post-procedural erythema significantly being reduced, achieving faster, more effective skin rejuvenation.

EXOSOMES DERIVED FROM THE STEM CELLS OF EDELWEISS FLOWER

Edelweiss, scientifically known as Leontopodium alpinum, a botanical marvel native to the rugged, high-altitude regions of the European Alps, often referred to as the "queen of the Alps," thrives in some of the harshest environments on Earth, enduring intense UV radiation, extreme cold, and nutrient-poor soils. Edelweiss is easily recognised by its distinctive star-shaped, woolly white flowers surrounded by fuzzy bracts, an endemic adaptation for own protection.

Rich in natural antioxidants as leontopodic acid and flavonoids, Edelweiss has a remarkable ability to neutralise free radicals, reduce inflammation, and protect against oxidative stress. Its anti-aging, longevity-promoting properties stem from its robust cellular mechanisms, developed over millennia survival.

EXOSOMES VERSUS POLYNUCLEOTIDES

Exosomes and polynucleotides are both promising tools in regenerative medicine, but they differ in their mechanisms and range of effects. Exosomes offer a broader spectrum of advantages due to their multifunctional nature and to the multitude of regenerative actives their cargo contains, including polynucleotides.

While polynucleotides have a single-ingredient formulation of peptides and primarily focus on skin hydration and repair as a primer, exosomes take regeneration to a cellular level.

Exosomes act as natural messengers, delivering bioactive molecules and functionalised growth factors directly to target cells.This allows them to influence a wide range of cellular activities, from reducing inflammation and controlling pigmentation to stimulating collagen and elastin production.