POLYNUCLEOTIDE SKIN BIOSTIMULATION

Polynucleotides are versatile biopolymers derived from wild salmon DNA fragments with significant applications in regenerative facial aesthetics.

Structurally, Polynucleotides are long-chain molecules made from repeating nucleotide units that function in cellular repair and regeneration. Sodium DNA is highly biocompatible, meaning it is easily accepted by human skin without triggering adverse immune responses. This makes it ideal for those looking for natural skin rejuvenation without the risks associated with synthetic chemicals.

Polynucleotides have the ability to bind large amounts of water, forming a 3D gel that enhances hydration. This hydrophilic quality, combined with their gradual enzymatic breakdown, allows Polynucleotides to sustain moisture and support cellular activity over extended periods.

In addition they act as free radical scavengers, protecting skin cells from oxidative stress, which is crucial for mitigating damage from environmental factors like UV radiation. Additionally, the activation of purinergic receptors, especially the adenosine A2A receptor, triggers anti-inflammatory responses and promotes tissue repair by inhibiting NF-kB signalling, which regulates pro-inflammatory cytokine production. As a result Polynucleotide therapy can calm the skin and reduce redness, which makes it effective for sensitive or inflamed skin.

Polynucleotides have also the ability to induce bio-stimulation, influencing fibroblast activity and collagen synthesis. They initiate cellular pathways that increase the proliferation and migration of cells like fibroblasts and endothelial cells, supporting extracellular matrix remodeling. This leads to enhanced cell turnover, improved skin texture, and reduction in fine lines and wrinkles.

In aesthetic applications, Polynucleotides enhance skin elasticity and texture, promote wound healing, and reduce signs of aging by stimulating cellular repair mechanisms and enhancing hydration. Their effects are observed in the thickening of dermal layers and restructuring of adipose tissue, which together lead to improved skin tone, reduced wrinkles, and an overall rejuvenated appearance.

Their ability to stimulate collagen and elastin production, reduce inflammation, protect against free radicals, and maintain hyaluronic acid levels makes them highly effective for long-term skin health and rejuvenation.

These properties makes skin polynucleotides a valuable addition to skin therapies focused on achieving natural, long-lasting regenerative outcomes.